Research Areas

Good correlation between numerical simulation and experimental results

DENSE MICROFLUIDICS SIMULATION

Microfluidics at high particle concentrations (> 1 vol%) are not very well understood due to complex particle-particle interaction. We have developed a Dense Suspension Inertial Microfluidics Theory (DENSE-IMPACT) Simulation that can accurately model inertial microfluidics at high particle concentrations.

DENSE INERTIAL MICROFLUIDICS

In the area of dense suspension microfluidics, we have made a new scientific discovery, which eventually led to an invention which has been described as “disruptive” by a big biopharmaceutical company. We intend to spin-off a company based on this invention and have developed a minimum viable product (MVP) that is currently being evaluated in a biopharmaceutical MNC in USA.

MICRO-BIOREACTOR ORGAN-ON-A-CHIP

We have utilized our capabilities in designing complex microbioreactors for organ-on-a-chip applications. Shown here is our proprietary uBioChipX model for Gut Microbiome studies integrating anaerobic gut microbiome with primary gut epithelial cells on Transwells and oxygenated immune cells below.

SPACE MICRO-BIOREACTOR

We will be developing a space bioreactor integrated with real-time sensors and feedback control for intelligent feeding. We will also be developing a similar bioreactor for microgravity experiments for rapid aging testing of novel anti-aging drugs.

Featured Publications

An Eng Lim and Shireen Goh (2023) Effect of Microchannel Diameter on Electroosmotic Flow Hysteresis. Energies 16(5): 2154

Danielle S. Tan and Shireen Goh (2016) A Numerical Model of Microfluidic Inertial Separation. In Proceedings of the 20th Australasian Fluid Mechanics Conference, AFMC 2016

Shireen Goh, Shan Mei Tan, Danielle S. Tan, Yuan Sheng Yang (2016) New phenomenon: Outer wall focusing at high cell densities enables high performance cell microfilter at low shear stress. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, C.

Gajendra P. Singh, Shireen Goh, Michelangelo Canzoneri and Rajeev J. Ram (2015) Raman spectroscopy of complex defined media: biopharmaceutical applications. Journal of Raman Spectroscopy 46(6): 545-550

Wee Yang Ng, Shireen Goh, Yee Cheong Lam, Chun Yang and Isabel Rodríguez (2009) DC-biased AC-electroosmotic and AC-electrothermal flow mixing in microchannels. Lab On A Chip 9: 802-809

Sheng Shen, Arvind Narayanaswamy, Shireen Goh and Gang Chen (2008) Thermal conductance of bimaterial microcantilevers. Applied Physics Letters 92: 063509

Saikat Ghosh, Amar R. Bhagwat, C. Kyle Renshaw, Shireen Goh, Alexander L. Gaeta, and Brian J. Kirby (2006) Low-Light-Level Optical Interactions with Rubidium Vapor in a Photonic Band-Gap Fiber. Physical Review Letters 97: 023603

Landmark Patents and Intellectual Properties

S. Goh and S.M. Tan (2016) Outer Wall Focusing in Rectangular Spiral Channels for Particles and/or Cells Filtration at High Concentrations with applications in Microbioreactors/Water Filtration/Perfusion Well Plate Culture/Point-of-Care devices International Patent Application No. PCT/SG2017/050373, filed 21 July 2017. Patent granted in Singapore, China and Japan. Patent pending in Europe and USA.

S. Goh, R.J. Ram, M. Canzoneri and H. Blum (2014) Small Volume Bioreactors with Substantially Constant Working Volumes and Associated Systems and Methods International Patent Application No. PCT/US2014/052252, filed 22 August 2014.

S. Goh, R.J. Ram, M. Canzoneri and H. Blum (2013) Control of Carbon Dioxide Levels and pH in Small Volume Reactors, U.S. Patent Application No. 14/063,907 and International Patent Application No. PCT/US2013/066832, filed October 2013.

S. Goh, K.S. Lee, R.J. Ram, M. Canzoneri and H. Blum (2013), Humidity Control in Chemical Reactors, U.S. Patent Application No. 14/064,021 and International Patent Application No. PCT/US2013/066845, filed October 2013.